CBD Drug Interactions

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CBD Drug Interactions

CBD is a drug; we created NCPA CBD Source because of this simple fact. As such, there are several inadequately addressed issues facing the CBD industry, the most important of which is the presence of CBD-drug interactions.

Pharmacokinetic Interactions

Most drug-drug interactions are pharmacokinetic in nature. A pharmacokinetic interaction occurs when one drug alters the blood levels of another drug. Drug blood levels are largely correlated with their hepatic metabolization by the cytochrome P450 (CYP450) system of enzymes. When two drugs are metabolized by the same CYP enzyme, an interaction is likely to occur.

The CYP450 system is responsible for the biotransformation of approximately 85% of all ingested substances, including drugs. As with most proteins, a single substance can be both a substrate (the protein acts on the drug) and an inhibitor/inducer (the drug acts on the protein) of the CYP450 enzymes. We must be equally aware of these influences when considering CBD-drug interactions.

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