Mechanism of Action

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CBD Mechanisms of Action

CBD is a phytocannabinoid molecule with several unique properties, including a hydrophobic tail, a hydrophilic aromatic moiety, and two hydroxy groups. This diverse array of functional groups gives CBD the ability to act on more than 65 different targets in the human body. Below we outline a few of the better understood mechanisms of CBD in the human body.

CBD and Cannabinoid Receptors

CBD is a negative allosteric modulator of CB1 and CB2 cannabinoid receptors.

This has several implications.

  1. - Firstly, negative modulation of CB1 receptors reduces the perceived effects of cannabinoid agonists, like THC.
  2. - Secondly, it causes upregulation of the same CB1 receptors, which improves signaling and reduces the likelihood of endocannabinoid deficiency [1] [2].

What is the role of cannabinoid receptors?

Cannabinoid receptors are the most widely expressed G protein-coupled receptors in humans: they’re more numerous than all other GPCRs combined.

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